Loss on Drying (LOD) Calculator

PHARMACAL SUITE

Loss on Drying (LOD) Calculator

Calculate Moisture Content % and Total Solids %

Initial Sample Weight (g) (Wet Weight)

Final Sample Weight (g) (Dry Weight)

Loss on Drying (LOD): 0.00 %

Total Solids Content: 0.00 %

Formula Used: -

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Understanding Loss on Drying (LOD)

Loss on Drying (LOD) is a standard test method (e.g., USP <731>) used to determine the amount of volatile matter (usually water) in a pharmaceutical sample. It typically involves heating the sample below its melting point in an oven until it reaches a constant weight.

Step 1: Weigh Initial Sample

Weigh the sample container (tare), add the sample, and record the Initial Wet Weight. Ensure the balance is calibrated.

Step 2: Dry the Sample

Place the sample in a drying oven or moisture analyzer at the specified temperature (e.g., 105°C) for the required time period.

Step 3: Weigh Final Sample

After cooling in a desiccator, weigh the sample again to obtain the Final Dry Weight. Enter both values above to calculate the percentage loss.

Key Calculation Formula

LOD % = [(W_initial - W_final) / W_initial] × 100

Where W_initial is the wet weight and W_final is the dry weight.